Cyclooxygenase Inhibition and Adverse Remodeling During Healing After Myocardial Infarction
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase inhibition and adverse remodeling during healing after myocardial infarction.
For over 2 millennia, physicians have strived to relieve pain, heal, and cause no harm. However, we depend on therapeutic drugs that have side effects and unknown pleiotropic effects. A host of publications and media coverage over the last 2 years alerted us to cardiovascular (CV) risks associated with chronic use of nonselective, nonsteroidal antiinflammatory drugs (NSAIDs) and selective cyclo...
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Adverse ventricular remodeling during the healing phase after acute myocardial infarction (MI) continues to be an important problem that impacts adult cardiology practice. Most clinicians and cardiovascular researchers recognize that significant left ventricular (LV) remodeling occurs during infarct healing, and optimal healing is critical for survival with a favorable outcome. Over the last 3 ...
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Over the last decade there has been growing interest in “bedside” protein and cellular markers of inflammation and adverse outcome after acute myocardial infarction (AMI) (1–16). In this issue of the Journal, Maekawa et al. (17) address the prognostic significance of peripheral monocytosis found at two to three days after reperfused AMI as a cellular marker for clinical outcome and its possible...
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BACKGROUND Myocardial infarction (MI) is a leading cause of heart failure and death worldwide. Preservation of contractile function and protection against adverse changes in ventricular architecture (cardiac remodeling) are key factors to limiting progression of this condition to heart failure. Consequently, new therapeutic targets are urgently required to achieve this aim. Expression of the Ru...
متن کاملHealing after myocardial infarction.
Wounding and healing are archaic principles, prerequisite for survival of any biologic material. However, strategies to cope with wounding may be quite different among organisms, species, or among various organs of one species. Today, myocardial infarction and the consequent loss of fully functional myocardium is the major aetiology for heart failure. Despite aggressive primary therapy, prognos...
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ژورنال
عنوان ژورنال: Circulation
سال: 2007
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.106.675306